[Daily Schedule]
- Morning session: lecture from 9am to noon.
- Afternoon session: practical from 2pm to 5pm.
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[Monday the 14th]
Standards and tools for sequences and 3D structures of immunoglobulins:
IMGT®, the international ImMunoGeneTics information system
Instructors:
Marie-Paule Lefranc and Patrice Duroux,
CNRS and University of Montpellier -- IMGT
Slides:
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Topics:
- Immunoglobulins: a primer,
- IMGT, the international ImMunoGeneTics information system,
- Analyzing sequences of IG,
- Analyzing structures of IG.
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[Tuesday the 15th]
Basic concepts and novel algorithms for modeling antibodies and their interactions
Instructors:
Charles H. Robert, CNRS / IBPC, France
Juan Cortés, LAAS / CNRS, Toulouse, France
Slides:
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Topics:
- Biophysics of protein interactions: a primer,
- Docking algorithms,
- Modeling proteins as robots to enhance conformational sampling,
- Cost-based motion-planning algorithms to efficiently compute transition paths of highly flexible molecules.
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[Wednesday the 16th]
Modeling antibody - antigen complexes: predicting binding affinity and interaction specificity
Instructor:
Frédéric Cazals ,
Inria / Algorithms-Biology-Structure, Inria Sophia Antipolis
Slides:
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Topics:
- Modeling interfaces of macro-molecular complexes,
- Basics in regression analysis,
- Basics in geometric modeling with Voronoi diagrams,
- Predicting binding affinities for IG - Ag complexes,
- Analyzing the interaction specificity of IG,
- Corresponding tools in the Structural Bioinformatics Library.
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[Thursday the 17th]
In-silico structure based design of antibodies
Instructor:
Charlotte Deane, Oxford University
Slides:
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Topics:
- SABDAB – the antibody structure database,
- ABodybuilder -- automated antibody structure prediction with data-driven accuracy estimation,
- Orientating the VH and VL domains,
- Predicting CDR-H3 rapidly and accurately,
- Paratopes and Epitopes – predicting and designing binding.
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[Friday the 18th]
Visualizing binding assay data using antigenic cartography
Instructor:
David F. Burke, Cambridge University
Slides:
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Topics:
- Theory of antigenic cartography,
- Influenza viruses,
- Example application: understanding the antigenic drift of influenza viruses.
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